Why Am I Suddenly Allergic to Products I Never Reacted to Before?

redness around lips caused by allergy

Allergic contact dermatitis from beeswax in lip balm. The allergy developed slowly over many years until one day symptoms appeared.

You’ve used the same lip balm forever, and you never had a reaction to it before.  But all of a sudden (it seems), you have itchy lips or a bit of a red rash around your mouth or even a few small, itchy bumps.  If you really think about it, maybe you recall this happening a few times in the past, but the symptoms were no big deal and would go away on their own.  Now the itching and redness is coming on faster after applying the lip balm and it lasts longer than it previously used to.  Sound familiar?  This is allergic contact dermatitis and while it appears to develop rather suddenly, that is not exactly the case.  The inflammatory response that leads to these kinds of skin rashes is a complex series of events within your immune system that develops over time.

Type IV Hypersensitivity Reactions

In immunology (the branch of biology/medicine concerned with immune responses), the most commonly used classification system of immune reactions recognizes 4 types of hypersensitivity reactions. In allergic contact dermatitis, we are concerned with Type IV Hypersensitivity Reactions.  Generally, these types of reactions are designed to protect your body from possible damage caused by microbial and foreign agents (virus, bacteria, foreign tissues).   When your body is first exposed to the invader, you become sensitized – you develop a sensitivity to it, in the hope that your body will recognize the invader again in the future and will mount an immune attack against it before it causes harm to your tissues.  But allergic contact dermatitis is a deviant form of these hypersensitivity reactions; it develops in a similar way, but instead of protecting your body from the allergen, the immune response actually causes damage to your skin.

Delayed hypersensitivity reactions

Type IV Hypersensitivity Reactions are cell-mediated immune responses – they require a series of interactions between various cells in the immune system in order to create sensitization in an individual.  That means several steps need to be taken before a person becomes sensitive to a substance.  Thus, these types of hypersensitivity reactions are sometimes referred to as “delayed hypersensitivity reactions.”  Most allergens are relatively weak in eliciting a response from the immune system and it takes several instances of exposure before sensitization occurs (although some, like poison ivy, are so strong that it only takes 2 exposures before this occurs).  Once a person is sensitized, subsequent reactions to the allergen occur more quickly.  Each time a person is re-exposed to the substance, the immune system responds faster and with more cells to trigger the inflammatory reaction.  It may take days, weeks, months or years, but eventually the tolerance threshold is breached and visible/palpable/sensory symptoms appear – such as itching, redness, swelling, skin lesions (papules, vesicles). Symptoms may resolve shortly after all contact with the allergen is discontinued, or they may linger for up to a month.

How sensitive a person is to developing allergic contact dermatitis depends on a few factors

  • Poor genetics (some people have more genetic factors that make them susceptible to developing allergic contact dermatitis)
  • Compromised skin barrier (seen in atopic patients, excessively dry skin, skin already compromised by dermatitis or ulcers)
  • Fewer suppressor cells (cells in the immune system that actually increase a body’s tolerance to allergic substances)
  • Increased frequency of re-exposure to the allergen
Once an allergic response is elicited, the intensity and duration of symptoms then varies based on these factors:
  • The person’s level of sensitivity to the allergen
  • The concentration of allergen absorbed by the skin
  • Duration of exposure to the allergen
  • Location of exposure to the allergen (a stronger response usually occurs at the original site of initial exposure)

What can be done to cure allergic contact dermatitis?

So what can be done to cure allergic contact dermatitis?  Well, it seems that once a person is sensitized to a particular substance, that substance needs to be avoided. So if you discover you are suddenly reacting to your lip balm, you need to figure out which ingredient is causing the reaction and then avoid it.  For example, propolis (found in beeswax) is a very common allergen and one that is easily avoided if you choose a lip balm that uses a different kind of wax.   It can take a lot of detective work to determine which exact substances are the culprit.  Skin patch testing can be helpful though it is not without error and it can be expensive.  For a list of common allergens found in lip and skin care products, read our popular post about recurrent rashes around the mouth/lips. It is possible to significantly reduce your risk of developing allergic contact dermatitis from skin care products you use regularly.  This can be achieved if you “chop & change” –  rotate the use of products so you aren’t using the exact same thing on your skin every day.  This is especially important for people with atopic eczema.  For instance, find 2 or 3 cleansers you like.  Switch your cleanser every 3 days and consider choosing a different one for day/night use. Do the same for moisturizers, shampoo, lip balm, make-up or any products that contact your skin daily. Save Save Save Save Save Save Save

Tags: allergic contact dermatitis, allergic dermatitis, allergic reaction, allergic skin reaction, allergy, contact dermatitis, dermatitis, featured, hypersensitivity reaction, irritated lips, keep, Type IV Hypersensitivity

Topics: Allergies, Eczema, Rashes

Publish Date: June 6, 2017     *Articles may include updates since original publishing.

About the Author ()

Diana Hermann is a licensed acupuncturist and board certified in Chinese Herbal Medicine. She received her Master Degree in Acupuncture and Oriental Medicine from the Oregon College of Oriental Medicine in Portland, OR and trained in China at the Nanjing University of Traditional Chinese Medicine. Diana treats patients in her Fort Collins, Colorado clinic and hand crafts herbal skin care products for her company Zi Zai Dermatology. In 2015, she completed the Diploma In Chinese Medicine Dermatology program from Avicenna in London, UK. She completed the program for a second time in 2019 in Chicago.

Comments (9)

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  1. Tiffany says:

    Have had a rash around my lip linner that’s itchy and sometimes burns. Went to doctors one said that’s it’s contact dermatitis the other said that’s it. Is atopic dermatitis gave me hydrocortisone cream and told me to take Zyrtec D. But the issue is I also have IBS and it seems like every time I have a flare up my lips do to. It’s only on the top lip on the linner on one side. Help I just don’t know what to do. I need something it goes and comes.i want. It gone and another thing when I eat certain food it triggers it too and also diabetic too.

    • Nicky says:

      Have you told your doctor that the lip rash coincides with the IBS…maybe you should tell your gastroenterologist. I feel for you, having some biopsies done myself…I hope you feel well soon .

    • Miriam says:

      Please tell your doctor about the timing of the rash (how it happens when you have IBS flares). This could be a sign of Chron’s disease.

  2. winnie wong says:

    Hi, i have same issue if wrongly use lip balm or use wrongly product & wrongly eat some food.Will make my lips itchy,rashes,got blister,peeling n crack & cause to bleeding.
    Any sollution for this & fyi i already email to you my pic.
    Waiting for your advise.
    Thank you.

  3. Jennifer says:

    I use to use plain chapstick for years and got a reaction to it and was told to use vaseline, which worked for about 6 years and then last year I got a bad reaction to it, switched over to a organic dr bronner lip balm with only avocado oil, jojoba oil, beeswax, hemp seed oil and tocopherol which has worked fine for about 9 months, I then decided to try aquaphor lip repair because I learned it did not contain petroleum, it worked for about 2 months and I started to developer red blotchy bump areas but would come and go every week, so I switched back to the organic balm and it is still doing the same thing. Anyone know if it’s normal to have a reaction to something but it will come and go weekly? It will seem like it heals almost up and then boom the same blotchy red irritation in the same spots everytime. Ordered some of the beeswax free lip balm and salve from here and I hope it works when it comes.

  4. Thanks for pointing out that allergies can sometimes be genetic in nature so I wouldn’t need to alter my lifestyle in order to avoid it. I recently ate a Japanese dish with octopus in it and it caused some mild irritation on my touch before I could eat it all. I would like to know if this is caused by me being allergic to it or if it’s just something about how the dish was prepared so I better start looking for an allergen testing service soon.

  5. Andrea Senghore says:

    I have used deep heat spray for as long as I can remember., yesterday I sprayed some on my back as I usually do and my whole body and face became bright red and was burning for at least 20 minute.also had a cramp in my stomach. Never had this happen before.

  6. Samia chowdhury says:

    Last month i got terrible face allergie.my skin was burnt.and whole face was covered with rashes.i was fasting that time and skiped my skin care products for few days and then i got this allergie.my skin was so good now i can’t even watch myself on mirror.the allergy was gone after i started using my skincare again.then i just the day before ywsterday i skiped my skin care again and the allergies are back again.i stopped using the cream i was using but continued with the toner,2%bha exfoliator,essence and moisturiser but my skin burns after using them.i don’t know how can i cure this.

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